Journal article
β-blockade prevents coronary macro- And microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto–Kakizaki rat
JT Pearson, HP Thambyah, MT Waddingham, T Inagaki, V Sukumaran, JP Ngo, CPC Ow, T Sonobe, YC Chen, AJ Edgley, Y Fujii, CK Du, DY Zhan, K Umetani, DJ Kelly, H Tsuchimochi, M Shirai
Clinical Science | PORTLAND PRESS LTD | Published : 2021
DOI: 10.1042/CS20201441
Abstract
A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress and endothelial dysfunction. Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) have been shown to abolish inflammation and redox stress but only partially restore endothelial function in mesenteric vessels. We investigated whether sympatho-adrenal overactivation evokes coronary vascular dysfunction when a high salt intake is combined with insulin resistance in male Goto–Kakizaki (GK) and Wistar rats treated with two different classes of β-blocker or vehicle, utilising synchrotron-based microangiography in vivo. F..
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Awarded by National Cerebral and Cardiovascular Center
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council Senior Research Fellowship and Programme grant [grant number 1092642 (to D.J.K.)]; travel funded by the International Synchrotron Access Program [grant number ISAP, AS/IA131] managed by the Australian Synchrotron, part of ANSTO, and funded by the Australian Government; the Intramural Research Funds [grant numbers 22-2-3, 22-3-2] of the National Cerebral and Cardiovascular Center; and the JSPS KAKENHI [grant number 19H03405].